Cytat:Summary from the Patent (WO2017020002A1)
DXE = N-ethyl analog of dextromethorphan (DXM)
🧪 Key details from the patent:

• Goal of development: to produce non-centrally active NMDA antagonists for treating type 2 diabetes, pancreatic β-cell protection, and neuroprotection without dissociative effects.
  
• Rationale: DXM and dextrorphan (DXO) show protective effects on insulin-producing cells, but their CNS effects (dissociation, hallucinations) are undesirable for therapeutic use.
  
• Structural change: Replacing the N-methyl group with an ethyl changes:
  • Metabolic profile
    
  • Blood-brain barrier (BBB) permeability
    
  • Possibly receptor affinity (especially sigma-1 and NMDA)
    
• Claimed benefits of DXE:
  • Lower CNS penetration
    
  • Longer plasma half-life
    
  • Maintained or improved peripheral NMDA receptor modulation
    
  • Potential for once-daily dosing
    

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🧠 What Might DXE Feel Like Recreationally?

Cytat:🚨 Important disclaimer: DXE was not developed for recreational use, and its pharmacokinetics in humans are unknown. The following is a speculative analysis based on structure-activity relationships (SAR) and analog behavior.

📊 Expected Pharmacological Effects (compared to DXM):

 

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💊 Predicted Subjective Effects (if taken recreationally):

• Dose: Likely slightly higher than DXM for psychoactive effects (i.e., 150–300 mg range for threshold activity)
  
• Onset: Slower (due to N-ethyl slowing metabolism)
  
• Duration: Possibly longer — 8–12 hours or more
  
• Headspace:
  • Possibly clearer or "emptier" than DXM
    
  • May feel less dreamy or "spiritual"
    
• Dissociation:
  • Present, but potentially muted or more physical than visual
    
• Body load:
  • Could be heavier due to slower elimination
    
• Euphoria:
  • Likely reduced compared to DXM/DXO
    
• Psychosis potential:
  • Lower, unless taken in large doses
    
• Afterglow/hangover:
  • Possibly milder due to reduced CNS stress
    

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🧪 Could it be abusable?
Potentially — especially by experienced dissociative users curious about obscure DXM analogs. But:

• The blunted CNS penetration may make it disappointing or “flat” compared to DXM.
  
• Some may find it preferable for a longer-lasting, less chaotic dissociation, especially with fewer visuals or emotional depth.
  

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🧠 TL;DR
DXE is an N-ethyl analog of DXM developed for therapeutic use without dissociative side effects. If used recreationally, it would likely produce a weaker, slower-onset dissociation, with less emotional richness or euphoria, but possibly longer duration and lower toxicity. It might appeal to hardcore dissociative explorers but would probably be less satisfying than DXM for most users.