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Nowości ze świata RC
30.11.2023, 22:37
U jednego z orientalnych hurtowników pojawił się opioid o dumnej nazwie SR-17018.
IUPAC NAME: 5,6-dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one
Chemical formula: C19H18Cl3N3O
Molar mass: 410.72 g•mol−1
CAS Number:2134602-45-0
Wygląda jak modyfikacja tego pseudo-fentalogu "brorphine" tylko że obłożona chlorem. Albo pochodna bezitramidu. Też obłożona chlorem.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348759/
https://www.sciencedirect.com/science/ar...0820305074
Cytat:SR-17018 is a drug which acts as a biased agonist at the μ-opioid receptor, selective for activation of the G-protein signalling pathway over β-arrestin 2 recruitment.[1] In animal studies it produces analgesic effects but with less respiratory depression and development of tolerance than conventional opioids.
IUPAC NAME: 5,6-dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one
Chemical formula: C19H18Cl3N3O
Molar mass: 410.72 g•mol−1
CAS Number:2134602-45-0
Wygląda jak modyfikacja tego pseudo-fentalogu "brorphine" tylko że obłożona chlorem. Albo pochodna bezitramidu. Też obłożona chlorem.
![Podobno kultowa Podobno kultowa](https://dopal.org/images/smilies/drug2.png)
Cytat:(...) repeated administration of SR-17018 produces tolerance as does morphine and oxycodone. SR-17018 retains efficacy in a formalin-induced inflammatory pain model upon repeated dosing, while oxycodone does not. In a chemotherapeutic-induced neuropathy pain model SR-17018 is more potent and efficacious than morphine or oxycodone, moreover, this efficacy is retained upon repeated dosing of SR-17018. These findings demonstrate that, with the exception of the tail flick test, SR-17018 retains efficacy upon chronic treatment across several pain models.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348759/
https://www.sciencedirect.com/science/ar...0820305074